PAWR CLIA Kit for Human(Homo sapiens) | EIAab.comPAWR CLIA Kit for Human(Homo sapiens)

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Index > Protein center > PAWR(Gene name) > Human

PAWR (Gene name),

PRKC apoptosis WT1 regulator protein (Protein name ), PAWR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PAWR(PAR4);

Protein name:

PRKC apoptosis WT1 regulator protein;

Alternative:

Prostate apoptosis response 4 protein(Par-4);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with WT1, via the C-terminal region. Homooligomer. Interacts also with a wide variety of proteins, such as atypical PKCs, p62, DAPK3 kinase and THAP1. Interacts with actin, AATF, BACE1, SPSB1, SPSB2 AND SPSB4. Component of a ternary complex composed of SQSTM1 and PRKCZ.

Function:

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Subcellular Location:

Cytoplasm Nucleus Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.

Protein Attributes:

Sequence length:

340

Sequence:

50:

100:

150:

200:

250:

300:

340:

GKLKEEIDLL | NRDLDDIEDE | NEQLKQENKT | LLKVVGQLTR |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:5074

MIM:

601936

UniGene:

Hs.643130

String:

Q96IZ0

STRING:

9606.ENSP00000328088

Uniprot:

Q96IZ0

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ELISA Kit for Human PRKC apoptosis WT1 regulator protein

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E15496h

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96T

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ELISA Kit for Human PRKC apoptosis WT1 regulator protein

Cat.:

E15496m

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96T

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ELISA Kit for Human PRKC apoptosis WT1 regulator protein

Cat.:

E15496r

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96T

CLIA Kit for Human PRKC apoptosis WT1 regulator protein

Cat.:

U15496m

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Packing:

96T

CLIA Kit for Human PRKC apoptosis WT1 regulator protein

Cat.:

U15496r

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MSDS:

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Packing:

96T

CLIA Kit for Human PRKC apoptosis WT1 regulator protein

Cat.:

U15496h

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96T

Polyclonal Antibody for Human PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PRKC apoptosis WT1 regulator protein

Protein for Human PRKC apoptosis WT1 regulator protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1."
Johnstone R.W. , See R.H. , Sells S.F. , Wang J. , Muthukkumar S. , Englert C. , Haber D.A. , Licht J.D. , Sugrue S.P. , Roberts T. , Rangnekar V.M. , Shi Y.
Mol. Cell. Biol.16:6945-6956(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH WT1
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-78
3.

NIEHS SNPs program
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-42; ARG-78; ALA-137 AND ALA-202
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
5.

"Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4."
Hsu S.-C. , Kirschenbaum F. , Miller J. , Cordell B. , McCarthy J.V.
Gene295:109-116(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64
tissue: Blood.
6.

"Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression."
Chakraborty M. , Qiu S.G. , Vasudevan K.M. , Rangnekar V.M.
Cancer Res.61:7255-7263(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS AND TUMOR REGRESSION
7.

"p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition."
Chang S. , Kim J.H. , Shin J.
FEBS Lett.510:57-61(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1 AND PRKCZ
8.

"THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies."
Roussigne M. , Cayrol C. , Clouaire T. , Amalric F. , Girard J.-P.
Oncogene22:2432-2442(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH THAP1
9.

"AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."
Guo Q. , Xie J.
J. Biol. Chem.279:4596-4603(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AATF
10.

"PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein."
Xie J. , Guo Q.
J. Biol. Chem.280:13824-13832(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BACE1
11.

"Structural basis for protein recognition by B30.2/SPRY domains."
Woo J.S. , Suh H.Y. , Park S.Y. , Oh B.H.
Mol. Cell24:967-976(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPSB1 AND SPSB2;MUTAGENESIS OF ASN-72
12.

"Apoptosis by Par-4 in cancer and neurodegenerative diseases."
El-Guendy N. , Rangnekar V.M.
Exp. Cell Res.283:51-66(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN APOPTOSIS AND NEURODEGENERATIVE DISEASES
13.

"Par-4 inducible apoptosis in prostate cancer cells."
Gurumurthy S. , Rangnekar V.M.
J. Cell. Biochem.91:504-512(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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